The Mandeville lab focuses on the development and implementation of neuroimaging techniques and modalities and their applications addressing functional physiology and pharmacology. Major areas of contributions are occupancy/function measurements and models using simultaneous PET/fMRI, development and characterization of IRON fMRI, development and application of pharmacological fMRI, contributions to fMRI physiology, and development of fMRI in awake, behaving nonhuman primates.